Induction of human γ globin gene expression by histone deacetylase inhibitors
نویسندگان
چکیده
منابع مشابه
Induction of human globin gene expression by histone deacetylase inhibitors
http://bloodjournal.hematologylibrary.org/content/103/2/701.full.html Updated information and services can be found at: (1174 articles) Red Cells (1086 articles) Gene Expression Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in ...
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We investigated the induction of human globin gene activity by 3 classes of histone deacetylase inhibitors: amide analogues of trichostatin A, hydroxamic acid analogues of trapoxin, and scriptaid and its analogues. The screening consisted of measuring the effects of these compounds on and human gene promoter activity by using cultures of GM979 cells stably transfected with a construct containin...
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http://bloodjournal.hematologylibrary.org/content/90/5/2075.full.html Updated information and services can be found at: (1174 articles) Red Cells Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at...
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Histone deacetylase (HDAC) inhibitors can induce transcriptional activation of a number of genes and induce cellular differentiation as histone acetylation levels increase. Although these inhibitors induce apoptosis in several cell lines, the precise mechanism by which they do so remains obscure. This study shows that HDAC inhibitors, sodium butyrate and trichostatin A (TSA), abrogate interleuk...
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ژورنال
عنوان ژورنال: Blood
سال: 2004
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2003-02-0478